Rate volatility and asymmetric segregation diversify mutation burden in mutator cells.
I. T. Dowsett, J. Sneeden, B. Olson, J. Mckay-Fleisch, E. McAuley, S. R. Kennedy, A. J. Herr
The paper models how mutator phenotypes in budding yeast increase genetic heterogeneity through rate volatility and asymmetric mutation segregation.
bioRxiv · Jun 21, 2020Cancer Biology