BET inhibition sensitizes immunologically-cold Rb-deficient prostate cancer to immune checkpoint blockade
B. Olson, K. Chaudagar, R. Bao, S. Sharma-Saha, C. Hong, S. Rameshbabu, R. Chen, A. Thomas, A. Patnaik
This paper shows that BET inhibition makes immunologically cold Rb-deficient prostate cancer more responsive to immune checkpoint blockade by reprogramming the tumor microenvironment through STING/NF-κB/IFN signaling.
bioRxiv · Mar 24, 2022Cancer Biology