Author

A. J. Herr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:yeast· 3 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Bode· 1 shared A. M. Loeb· 1 shared A. R. Chia· 1 shared A. R. Ollodart· 1 shared B. Hearn· 1 shared B. Olson· 1 shared E. McAuley· 1 shared I. Dowsett· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bode

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

P. Jiang, A. R. Ollodart, V. Sudhesh, A. J. Herr, M. J. Dunham, K. Harris

The paper uses a modified fluctuation assay to identify natural mutator phenotypes in S. cerevisiae strains, revealing a 10-fold mutation rate range and distinctive mutation spectra in two strains.

bioRxiv · Jan 11, 2021Evolutionary Biology

Rate volatility and asymmetric segregation diversify mutation burden in mutator cells.

I. T. Dowsett, J. Sneeden, B. Olson, J. Mckay-Fleisch, E. McAuley, S. R. Kennedy, A. J. Herr

The paper models how mutator phenotypes in budding yeast increase genetic heterogeneity through rate volatility and asymmetric mutation segregation.

bioRxiv · Jun 21, 2020Cancer Biology

Spontaneous polyploids and antimutators compete during the evolution of mutator cells

M. Tracy, M. Lee, B. Hearn, I. Dowsett, L. Thurber, J. Loo, A. M. Loeb, K. Preston, M. Tuncel, N. Ghodsian, A. Bode, T. Tang, A. R. Chia, A. J. Herr

The paper shows that spontaneous polyploids and antimutator clones outcompete each other in mutator yeast cultures, with polyploids dominating in haploid and antimutators in diploid settings.

bioRxiv · May 9, 2020Cancer Biology