E. Meylan

Low STING expression in a transplantable KrasG12D/P53ko lung cancer model contributes to SiglecF+ neutrophil and CD103+Treg accumulation in tumors

The paper investigates the role of STING expression in lung cancer models, finding that low STING expression promotes an immunosuppressive tumor microenvironment with increased neutrophils and Tregs.

Efficient and specific Ly6G+ cell depletion: A change in the current practices toward more relevant functional analyses of neutrophils

The paper compares anti-Gr1 and anti-Ly6G antibodies for neutrophil depletion, showing anti-Ly6G's inefficacy in C57BL/6 mice but its potential for specific depletion when combined with a secondary antibody.

RANKL Signaling Sustains Primary Tumor Growth In Genetically Engineered Mouse Models Of Lung Adenocarcinoma

This study shows that blocking RANKL signaling reduces primary tumor growth in lung adenocarcinoma mouse models and suggests potential benefits for KRAS mutant lung cancer patients.