C. Caux

Spatial architecture of CD8+ T cells and DC subsets is critical for the response to immune checkpoint inhibitors in melanoma

This study examines the spatial organization of dendritic cell (DC) subsets and their interactions with CD8+ T cells in melanoma patients, finding that proximity between cDC1 and CD8+ T cells correlates with response to immune checkpoint inhibitors.

Spatial transcriptomics reveal pitfalls and opportunities for the detection of rare high-plasticity breast cancer subtypes

The paper uses spatial transcriptomics to identify specific markers for rare high-plasticity breast cancer subtypes, showing that bulk expression signatures are limited by stromal contamination.

CD4 T cells and neutrophils contribute to epithelial-mesenchymal transition in breast cancer

The paper shows CD4 T cells and neutrophils promote EMT in breast cancer by analyzing murine tumor models and human cohorts.

A Unique Polyfunctional IL-33-responsive ST2⁺ NK cell State Potentiates Antitumor Immunity and Response to Immunotherapy

The paper identifies a unique ST2+ NK cell state that enhances antitumor immunity and response to immunotherapy through IL-33 and IL-12 signaling.

Gene signature of circulating platelet-bound neutrophils is associated with poor prognosis in cancer patients

The paper identifies a gene signature in neutrophil-platelet aggregates (NPAs) associated with poor prognosis in cancer patients.

cDC1 and interferons promote spontaneous CD4+ and CD8+ T cell protective responses to breast cancer

This study shows that cDC1 and interferons are critical for CD4+ and CD8+ T cell responses against breast cancer, promoting infiltration and effector functions, and improving patient prognosis.

A novel combination of chemotherapy and immunotherapy controls tumor growth in mice with a human immune system

This study shows that combining anti-ICOS mAb with chemotherapy reduces tumor growth in humanized mice by enhancing CD8+ T cell activity and reducing Treg numbers.

Efficient and specific Ly6G+ cell depletion: A change in the current practices toward more relevant functional analyses of neutrophils

The paper compares anti-Gr1 and anti-Ly6G antibodies for neutrophil depletion, showing anti-Ly6G's inefficacy in C57BL/6 mice but its potential for specific depletion when combined with a secondary antibody.

Redefining mesothelioma types as a continuum uncovers the immune and vascular systems as key players in the diagnosis and prognosis of this disease

This study redefines mesothelioma as a continuum rather than distinct types, identifying immune and vascular pathways as key factors in prognosis and potential therapeutic targets.