NAD consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival
M. Murata, X. Kong, E. Moncada, Y. Chen, P. H. Wang, M. W. Berns, K. Yokomori, M. Digman
The paper shows PARP1 activation in response to DNA damage causes NAD+ depletion, leading to a metabolic shift to oxidative phosphorylation, which supports cell survival.
bioRxiv · Aug 7, 2018Cell Biology