X. Kong

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

Replicating enzymatic activity by positioning active sites with synthetic protein scaffolds

The paper demonstrates a computational strategy to design new PET hydrolases by replicating functional motifs from a template enzyme using deep learning and molecular computations, resulting in enzymes with high activity and thermostability.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

This study shows miR-574-5p activates TLR8 to drive autoimmune signaling and lupus progression by enhancing cytokine production, STAT1 activation, and autoantigen generation.

Molecular characterization of baculovirus-induced chromatin marginalization and architectural alteration

This paper identifies the molecular mechanisms of baculovirus-induced chromatin marginalization and structural changes, revealing the role of Lamin A/C-HP1a-H3K9me3 interactions and nuclear F-actin.

Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving calcium-calcineurin-NFAT signaling

The paper shows that combining DNMT inhibitors with selective EZH2 inhibitors enhances antiproliferative effects in colon cancer by modulating calcium-calcineurin-NFAT signaling and viral mimicry.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma

The paper identifies NDC80 as a predictor of ccRCC progression and shows that NDC80-high tumors are sensitive to mitotic kinase inhibitors.

HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

Isoform-specific Disruption of the TP73 Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via Leptin

This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.

Integrated single-nucleus and spatial transcriptomics captures transitional states in soybean nodule symbiosis establishment

The paper integrates single-nucleus and spatial transcriptomics to map transitional states in soybean nodule symbiosis, identifying functionally distinct cell subgroups and a transitional infected cell subtype.

An engineered xCas12i with high activity, high specificity and broad PAM range

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

Cohesin mutation sensitizes cancer cells to anti-PD-1 therapy through endogenous retrovirus-mediated PD-L1 upregulation

This study shows cohesin mutations enhance cancer cell sensitivity to anti-PD-1 therapy by increasing PD-L1 through endogenous retrovirus activation.

RNA2Immune: A Manually Curated Database of Experimentally Supported Data Linking Noncoding RNA Regulation to the Immune System

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

Progressive chromatin silencing of ABA biosynthesis gene permits seed germination in Arabidopsis

The paper shows that RZ-1 and PRC2 work together to silence NCED6, a gene involved in ABA biosynthesis, which is essential for seed germination in Arabidopsis.

Retron Editing for Precise Genome Editing without Exogenous Donor DNA in Human Cells

This study demonstrates retron editing enables efficient precise genome editing in human cells without exogenous donor DNA, achieving up to 10% editing rates at endogenous loci.

Auxin-triggered changes in the Arabidopsis root tip (phospho)proteome reveal novel root growth regulators

The paper identifies novel root growth regulators in Arabidopsis root tips through analysis of auxin-triggered (phospho)proteome changes.

Targeting KRAS-mutant stomach/colorectal tumours by disrupting the ERK2-p53 complex

This study identifies the ERK2-p53 complex as a therapeutic target in KRAS-mutant stomach/colorectal cancers, showing that disrupting it with MEK1/2 and ERK2 inhibitors induces apoptosis.

IP-MS Analysis of ESX-5 and ESX-1 Substrates Enables Mycobacterial Species Identification

The paper develops an IP-MS assay to identify slow-growing mycobacterial species in early MGIT cultures using species-specific antibodies.

SIZ1-mediated SUMOylation of ROS1 Enhances Its Stability and Positively Regulates Active DNA Demethylation in Arabidopsis

This study identifies SIZ1-mediated SUMOylation of ROS1 as a mechanism enhancing ROS1 stability and promoting active DNA demethylation in Arabidopsis.

DNA damage induced during mitosis undergoes DNA repair synthesis

This study uses laser-induced DNA damage in mitotic cells to show DNA repair occurs, is affected by DNA-PKcs and ATM, and reveals 25% of damaged cells proceed to mitosis.

Convergent genomic signatures of high altitude adaptation among domestic mammals

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

Validation of a Miniaturized Permeability Assay Compatible with CRISPR-Mediated Genome-Wide Screen

The paper validates a miniaturized permeability assay compatible with CRISPR-mediated genome-wide screens for thrombin-disruptive genes in endothelial cell junctions.

Circulating bacterial DNA as a tool towards non-invasive biomarkers for colorectal cancer and adenoma

This study identifies circulating bacterial DNA biomarkers for colorectal cancer and adenoma using plasma samples and a random forest model, achieving high accuracy in distinguishing between cancer, adenoma, and healthy controls.

PRH1 mediates ARF7-LBD dependent auxin signaling to regulate lateral root development in Arabidopsis thaliana

This study identifies PRH1 as a target of ARF7 and LBDs in auxin signaling, showing its role in lateral root development through interaction with GATA23.

LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization

The paper identifies Dnmt3aos as a lncRNA regulating Dnmt3a expression and DNA methylation in macrophage polarization, revealing its role in modulating IFN-gamma expression.

‘Chromatic’ Neuronal Jamming in a Primitive Brain

The paper identifies a new packing state in planarian brains called chromatic jamming, where distinct neuron types form independent percolating networks without physical contact.