Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral Activity
J. Börold, D. Eletto, I. Busnadiego, N. K. Mair, E. Moritz, S. Schiefer, N. Schmidt, P. P. Petric, W. W.-L. Wong, M. Schwemmle, B. G. Hale
This study identifies BRD9 as a critical component of IFN signaling and antiviral activity through CRISPR screening, showing its druggability for targeting constitutive ISG expression.
bioRxiv · Feb 4, 2021Immunology