N. Schmidt

Building Blocks of Understanding: Constructing a Reverse Genetics Platform for studying determinants of SARS-CoV-2 replication.

This paper develops a reverse genetics platform for SARS-CoV-2 to generate recombinant viruses and study their replication and phenotypic effects.

Adenovirus type 34 and HVR1-deleted Adenovirus type 5 do not bind to PF4: clearing the path towards vectors without thrombosis risk

The paper identifies adenovirus types and modified vectors that do not bind to PF4, reducing thrombosis risk in vaccine development.

A condensate forming tether for lariat debranching enzyme is defective in non-photosensitive trichiothiodystrophy

This study identifies TTDN1's role in linking intron lariat processing to the spliceosome, showing its defect causes splicing and gene expression issues in NP-TTD.

Solving the Sample Size Problem for Resource Selection Analysis

This paper provides mathematical expressions to determine optimal sample sizes for resource selection analyses, showing that fewer data may be sufficient for strong selection effects.

An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore with similarity to phosphatidylinositol-4,5-bisphosphat

This study identifies two independent mechanisms by which (R)-L3 activates Kv7.1 channels, involving allosteric modulation of the pore and electro-mechanical uncoupling.

Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral Activity

This study identifies BRD9 as a critical component of IFN signaling and antiviral activity through CRISPR screening, showing its druggability for targeting constitutive ISG expression.

Broken, silent, and in hiding: Tamed endogenous pararetroviruses escape elimination from the genome of sugar beet (Beta vulgaris)

The paper characterizes endogenous pararetroviruses in sugar beet genomes, showing their structural diversity, epigenetic suppression, and chromosomal localization.

A direct RNA-protein interaction atlas of the SARS-CoV-2 RNA in infected human cells

This study maps direct RNA-protein interactions of SARS-CoV-2 RNA in infected human cells using RAP-MS, identifying host factors, regulators, and potential drug targets involved in viral replication and host defense.

Cdk1-dependent destabilization of long astral microtubules is required for spindle orientation

This study shows that Cdk1 destabilizes astral microtubules to enable spindle reorientation in response to cell shape cues.

Clathrin’s adaptor interaction sites are repurposed to stabilize microtubules during mitosis

This paper identifies a novel role of clathrin in stabilizing microtubules during mitosis by repurposing its adaptor interaction sites to recruit GTSE1, which inhibits MCAK and supports chromosome congression.