Drug screens of NGLY1 Deficiency worm and fly models reveal catecholamine, NRF2 and anti-inflammatory pathway activation as potential clinical approaches
S. Iyer, J. D. Mast, H. Tsang, T. P. Rodriguez, N. DiPrimio, M. Prangley, F. S. Sam, Z. M. Parton, E. Perlstein
The paper identifies drug candidates that rescue growth in NGLY1-deficient worm and fly models by targeting NRF2, anti-inflammatory pathways, and catecholamine signaling.
bioRxiv · Aug 28, 2019Pharmacology & Toxicology