Pharmacology & ToxicologybioRxiv
Drug screens of NGLY1 Deficiency worm and fly models reveal catecholamine, NRF2 and anti-inflammatory pathway activation as potential clinical approaches
S. Iyer, J. D. Mast, H. Tsang…·E. Perlstein
The paper identifies drug candidates that rescue growth in NGLY1-deficient worm and fly models by targeting NRF2, anti-inflammatory pathways, and catecholamine signaling.
DOI 10.1242/dmm.040576