Cholesterol metabolism drives regulatory B cell function
J. A. Bibby, H. A. Purvis, T. Hayday, A. Chandra, K. Okkenhaug, M. Wood, H. J. Lachmann, C. Kemper, A. Cope, E. Perucha
This study shows that cholesterol metabolism, specifically through GGPP synthesis, is essential for regulatory B cell function by promoting IL-10 production and suppressing Th1 responses.
bioRxiv · Jan 3, 2020Immunology