A. Chandra

Aberrant TNF signaling in pancreatic lymph nodes of patients with Type 1 Diabetes

This study identifies heightened TNF pathway activity and chromatin remodeling in pancreatic lymph node CD4+ T cells from T1D patients, supporting the use of TNF inhibitors in clinical trials.

Avian influenza virus neuraminidase stalk length and haemagglutinin glycosylation patterns reveal molecularly directed reassortment promoting the emergence of highly pathogenic clade 2.3.4.4b A (H5N1) viruses

This paper identifies molecular factors driving the emergence of highly pathogenic H5N1 influenza viruses by showing HA glycosylation and NA stalk length determine subtype pairing and viral fitness.

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

Complex carbohydrate utilization by gut bacteria modulates host food preference

This study shows that gut bacteria ferment specific fructans, influencing host preference for non-fermentable fructan diets through neuronal activation in the hypothalamus.

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers

The paper identifies prognostically relevant co-expression patterns between coding and noncoding RNAs in HPV16-positive cervical cancers and links them to patient survival.

Transcriptional regulation of Dyskerin via canonical WNT signaling modulates sphingolipid biosynthesis and drives colorectal cancer.

This study identifies DKC1 as a key regulator in colorectal cancer progression through WNT signaling, showing its role in sphingolipid biosynthesis and proposing ceramides as potential biomarkers.

Probing single cell fermentation flux and intercellular exchange networks via pH-microenvironment sensing and inverse modeling

This study quantifies single cell fermentation fluxes and intercellular exchange networks using pH microenvironment sensing and inverse modeling in mixed cancer and fibroblast cultures, revealing heterogeneous proton trafficking and a crossover from hub-driven to dipolar exchange phases.

Peptide derived nanobody inhibits entry of SARS-CoV-2 variants

The paper identifies a nanobody that inhibits SARS-CoV-2 entry by targeting a peptide from the spike protein's receptor-binding motif, showing efficacy against multiple variants.

Identification of Cancer-Associated Fibroblasts in Glioblastoma and Defining Their Pro-tumoral Effects

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

Niclosamide inhibits SARS-CoV2 entry by blocking internalization through pH-dependent CLIC/GEEC endocytic pathway

Role of c-Met/β1 integrin complex in the metastatic cascade

This study identifies the c-Met/β1 integrin complex as a driver of breast cancer intravasation and bone metastasis, suggesting therapeutic targeting could prevent metastases.

Genetically encoded live cell sensor for tyrosinated microtubules

The paper develops a genetically encoded live cell sensor for tyrosinated microtubules and uses it to study drug-induced microtubule depolymerization.

Cholesterol metabolism drives regulatory B cell function

This study shows that cholesterol metabolism, specifically through GGPP synthesis, is essential for regulatory B cell function by promoting IL-10 production and suppressing Th1 responses.

O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer

This study shows that O-GlcNAc modification of Sox2 stabilizes the protein and enhances self-renewal in pancreatic cancer, with targeting OGT reducing tumor burden.

PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

This study identifies a PI3Kδ-driven B cell subset in the lungs that worsens Streptococcus pneumoniae infection independently of antibodies, and shows that inhibiting PI3Kδ improves survival.

Cells With Treg-Specific FOXP3 Demethylation But Low CD25 Are Prevalent In Autoimmunity

The paper identifies CD25lowFOXP3+ T cells as a subset of regulatory T cells expanded in autoimmune diseases, characterized by FOXP3 demethylation and distinct functional features.