ImmunologybioRxiv
Cholesterol metabolism drives regulatory B cell function
J. A. Bibby, H. A. Purvis, T. Hayday…·E. Perucha
This study shows that cholesterol metabolism, specifically through GGPP synthesis, is essential for regulatory B cell function by promoting IL-10 production and suppressing Th1 responses.
DOI 10.1038/s41467-020-17179-4