mTORC1 activity is supported by spatial association with focal adhesions
Y. Rabanal-Ruiz, A. Byron, A. Wirth, R. R. Madsen, L. Sedlackova, G. Hewitt, G. Nelson, J. Stingele, R. Faessler, B. Vanhaesebroeck, O. Maddocks, E. Ponimaskin, B. Carroll, V. I. Korolchuk
This study shows that mTORC1 activation by growth factors and amino acids requires its spatial association with focal adhesions, independent of lysosomal distribution.
bioRxiv · Nov 20, 2020Cell Biology