Author

A. Wirth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1

Frequent Co-Authors

M. Freichel· 3 shared B. Isermann· 2 shared J.-N. Boeckel· 2 shared K. Shahzad· 2 shared S. Fatima· 2 shared S. Gaul· 2 shared U. Laufs· 2 shared A. A. Teleman· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

M. Freichel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis

C. Maeder, T. Speer, M. Freichel, A. Wirth, J.-N. Boeckel, K. Shahzad, S. Fatima, B. Isermann, U. Laufs, S. Gaul

This study shows that membrane-bound IL-1α promotes leukocyte adhesion in atherosclerosis, while IL-1β and NLRP3 do not show similar protection.

bioRxiv · May 31, 2023Immunology

Deep metabolic profiling assessment of tissue extraction protocols for three model organisms

H. M. Gegner, N. Mechtel, E. Heidenreich, A. Wirth, F. G. Cortizo, K. Bennewitz, T. Fleming, C. Andresen, M. Freichel, A. A. Teleman, J. Kroll, R. Hell, G. Poschet

The paper evaluates extraction protocols for metabolomic profiling in three model organisms, finding a protocol that balances reproducibility and metabolite detection across tissues.

bioRxiv · Dec 16, 2021Biochemistry

A novel nongenetic murine model of hyperglycemia and hyperlipidemia-associated aggravated atherosclerosis

S. Gaul, K. Shahzad, R. Medert, I. Gadi, C. Meader, D. Schumacher, A. Wirth, S. Ambreen, S. Fatima, J.-N. Boeckel, H. Khawaja, J. Haas, M. Brune, P. P. Nawroth, B. Isermann, , M. Freichel

This paper establishes a nongenetic mouse model to study atherosclerosis under hyperlipidemia and hyperglycemia conditions and evaluates diet effects on plaque severity.

bioRxiv · Nov 11, 2021 · PreprintPharmacology & Toxicology

mTORC1 activity is supported by spatial association with focal adhesions

Y. Rabanal-Ruiz, A. Byron, A. Wirth, R. R. Madsen, L. Sedlackova, G. Hewitt, G. Nelson, J. Stingele, R. Faessler, B. Vanhaesebroeck, O. Maddocks, E. Ponimaskin, B. Carroll, V. I. Korolchuk

This study shows that mTORC1 activation by growth factors and amino acids requires its spatial association with focal adhesions, independent of lysosomal distribution.

bioRxiv · Nov 20, 2020Cell Biology