R. Faessler

The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation

The paper identifies USP12/46 deubiquitinases that prevent ESCRT-mediated lysosomal degradation of β1 integrin by removing ubiquitin from its cytoplasmic tail in early endosomes.

Rab7 deficiency induces lysosome formation from recycling endosomes leading to an increased degradation of cell surface proteins

Caskin2 is a novel talin and Abi1-binding protein that promotes cell motility

This study identifies Caskin2 as a novel talin-binding protein that enhances cell motility through interactions with Abi1 and the WAVE Regulatory Complex.

mTORC1 activity is supported by spatial association with focal adhesions

This study shows that mTORC1 activation by growth factors and amino acids requires its spatial association with focal adhesions, independent of lysosomal distribution.

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions

The paper shows kindlin uses membrane diffusion and localization to the integrin nano-layer to activate integrins in focal adhesions, distinct from talin's mechanism.

Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis

This study shows that active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis through interactions with the insulin receptor.