E. Puca

Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX

This study shows that combining SMDCs targeting carbonic anhydrase IX with immunotherapy enhances anticancer activity in mouse models of renal cell carcinoma and colorectal cancer.

Comparative evaluation of bolus and fractionated administration modalities for two antibody-cytokine fusions in immunocompetent tumor-bearing mice

This study compares bolus and fractionated administration of two antibody-cytokine fusions in mice, finding that fractionation reduces toxicity for one but increases efficacy for another.

The antibody-based delivery of interleukin-12 to solid tumors boosts NK and CD8+ T cell activity and synergizes with immune check-point inhibitors

This paper describes a fusion protein that delivers interleukin-12 to tumors, enhancing NK and CD8+ T cell activity and synergizing with checkpoint inhibitors.