Author

M. Matasci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Villa· 4 shared B. Gouyou· 4 shared D. Neri· 4 shared S. Cazzamalli· 4 shared T. Ongaro· 2 shared A. Kerschenmeyer· 1 shared C. Hutmacher· 1 shared E. Puca· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBioengineering

A. Villa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antibody-based delivery of Interleukin-9 to neovascular structures: therapeutic evaluation in cancer and arthritis

B. Gouyou, T. Ongaro, S. Cazzamalli, R. De Luca, A. Kerschenmeyer, P. Valet, A. Villa, D. Neri, M. Matasci

This study evaluates the therapeutic potential of IL9 delivered via antibody-based fusion proteins in cancer and arthritis models, finding modest anti-tumor activity but no benefit in arthritis.

bioRxiv · Aug 26, 2020Bioengineering

Sortase-mediated site-specific modification of interleukin-2 for the generation of a tumor targeting acetazolamide-cytokine conjugate

B. Gouyou, J. Millul, A. Villa, S. Cazzamalli, D. Neri, M. Matasci

This paper develops a tumor-targeting cytokine conjugate using Sortase A-mediated site-specific modification of interleukin-2 with acetazolamide, targeting carbonic anhydrase IX.

bioRxiv · Jul 20, 2020Bioengineering

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade

S. Dakhel, T. Ongaro, B. Gouyou, M. Matasci, A. Villa, D. Neri, S. Cazzamalli

This study shows that transient RIPK1 inhibition increases the tolerated dose of L19-TNF while preserving its antitumor effects and tumor targeting.

bioRxiv · Jul 30, 2019Pharmacology & Toxicology

The antibody-based delivery of interleukin-12 to solid tumors boosts NK and CD8+ T cell activity and synergizes with immune check-point inhibitors

E. Puca, P. Probst, M. Stringhini, P. Murer, G. Pellegrini, S. Cazzamalli, C. Hutmacher, B. Gouyou, S. Wulhfard, M. Matasci, A. Villa, D. Neri

This paper describes a fusion protein that delivers interleukin-12 to tumors, enhancing NK and CD8+ T cell activity and synergizing with checkpoint inhibitors.

bioRxiv · Jul 3, 2019Cancer Biology