Decoding Proteoforms with Single Acid Resolution Using a Sub-nanometer Diameter Pore
A. Paul, A. Rayabharam, P. Murkate, L. Almonte, E. Rigo, Z. Dong, A. Kumar, J. Joseph, N. R. Aluru, G. Timp
The paper demonstrates that sub-nanopore assays can decode proteoforms with single acid resolution by analyzing current fluctuations correlated with amino acid volumes and PTMs.
bioRxiv · Dec 22, 2022 · PreprintBiophysics