Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity
Y. Lang, W. Li, Z. Li, D. Koerhuis, A. C. S. van den Burg, E. Rozemuller, B.-J. Bosch, F. J. M. van Kuppeveld, G.-J. P. H. Boons, E. G. Huizinga, H. M. van der Schaar, R. J. de Groot
The paper shows that S and HE proteins co-evolve to balance attachment and release in coronaviruses, with functional interdependence observed in OC43 and HKU1.
Proceedings of the National Academy of Sciences · Sep 29, 2020Peer-reviewedMicrobiology