Author

Y. Lang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 2 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

F. J. M. van Kuppeveld· 3 shared R. J. de Groot· 3 shared B.-J. Bosch· 2 shared C. Qin· 2 shared D. L. Hurdiss· 2 shared I. Drulyte· 2 shared J. Chen· 2 shared J. Snijder· 2 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

F. J. M. van Kuppeveld

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Sialoglycan binding triggers spike opening in a human coronavirus

M. F. Pronker, R. Creutznacher, I. Drulyte, R. J. G. Hulswit, Z. Li, F. J. M. van Kuppeveld, J. Snijder, Y. Lang, B.-J. Bosch, G.-J. Boons, M. Frank, R. J. de Groot, D. L. Hurdiss

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

bioRxiv · Apr 20, 2023Microbiology

Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi

X. Zhao, X. Zhong, H. Wan, L. Liu, X. Song, Y. Zou, L. Li, R. Jia, J. Lin, H. Tang, G. Ye, J. Yang, S. Zhao, Y. Lang, Z. Yin, O. P. Kuipers

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

bioRxiv · Oct 7, 2022 · PreprintMicrobiology

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

C. Li, H. Zhou, L. Guo, D. Xie, H. He, H. Zhang, Y. Liu, L. Peng, L. Zheng, W. Lu, Y. Mei, Z. Liu, J. Huang, M. Wang, D. Shu, , C.-N. Qian

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

bioRxiv · Dec 14, 2021Pharmacology & Toxicology

Bat influenza vectored NS1-truncated live vaccine protects pigs against heterologous virus challenge

J. Lee, Y. Li, Y. Li, G. Cino-Ozuna, M. Duff, Y. Lang, J. Ma, S. Sunwoo, J. A. Richt, W. Ma

This study develops and tests bat influenza-based live attenuated vaccines for pigs, showing they reduce viral replication and lesions without causing vaccine-associated enhanced respiratory disease.

bioRxiv · Nov 18, 2020Microbiology

Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity

Y. Lang, W. Li, Z. Li, D. Koerhuis, A. C. S. van den Burg, E. Rozemuller, B.-J. Bosch, F. J. M. van Kuppeveld, G.-J. P. H. Boons, E. G. Huizinga, H. M. van der Schaar, R. J. de Groot

The paper shows that S and HE proteins co-evolve to balance attachment and release in coronaviruses, with functional interdependence observed in OC43 and HKU1.

Proceedings of the National Academy of Sciences · Sep 29, 2020Peer-reviewedMicrobiology

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

D. L. Hurdiss, I. Drulyte, Y. Lang, T. M. Shamorkina, M. F. Pronker, F. J. M. van Kuppeveld, J. Snijder, R. J. de Groot

The paper presents the cryo-EM structure of HKU1 HE, revealing structural changes due to prolonged human circulation, including a truncated lectin domain and intact esterase domain.

Nature Communications · Sep 16, 2020Peer-reviewedMicrobiology

Controlled-release urea combined with potassium chloride improved the soil fertility and growth of Italian ryegrass

j. geng, x. yang, x. huo, j. chen, S. Lei, h. li, y. lang, q. liu

This study shows that combining controlled-release urea with 300 kg ha-1 potassium chloride improves soil fertility, plant growth, and yield of Italian ryegrass.

bioRxiv · Jun 13, 2020 · PreprintPlant Biology

Swine Promyelocytic Leukemia Isoform II Inhibits Pseudorabies Virus Infection by Suppressing Viral Gene Transcription in PML-NBs

C.-l. Yu, A.-t. Xu, Y. Lang, C. Qin, X. Yuan, W.-h. Feng, M.-d. Wang, C. Gao, J.-w. Chen, R. Zhang, J. Tang

This study identifies sPML-II as the isoform that inhibits PRV infection by suppressing viral gene transcription through its 7b region.

bioRxiv · Mar 23, 2020Immunology

Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3

C. Qin, R. Zhang, Y. Lang, A.-w. Shao, A. Xu, W. Feng, J. Han, M. Wang, W. He, C. Yu, J. Tang

This study shows Bclaf1 is degraded by alphaherpesvirus US3 and is critical for type I interferon signaling and antiviral immunity.

bioRxiv · Aug 16, 2018Immunology