W. Li

Porphyromonas gingivalis promotes lipid droplet-mediated microglial dysfunction

This study shows Porphyromonas gingivalis infection increases lipid droplets in microglia, leading to oxidative stress and impaired function, which may contribute to Alzheimer's disease progression.

Negative feedback regulation of the hemi-arrestin MAPK scaffold Sms1 prevents untimely mating

The paper identifies Sms1 as a novel MAPK scaffold in fission yeast that regulates mating by negative feedback through membrane translocation.

TLR5 drives metabolic dysfunction-associated steatohepatitis through lipid- and flagellin-induced hepatocyte injury signalling

The paper investigates TLR5's role in MASH and fibrosis using clinical data, single-cell transcriptomics, and in vitro models, finding TLR5 drives hepatocyte injury and fibrosis through flagellin and lipid pathways.

Evolutionary persistence and divergence of the tdk killer meiotic driver family

The paper identifies divergent tdk1 homologs in fission yeast as active killer meiotic drivers, showing functional divergence and long-term evolutionary persistence.

Immunological evaluation in African Green Monkeys of two nasal vaccine candidates to induce a broad immunity against coronaviruses

This study evaluates two nasal coronavirus vaccines in African Green Monkeys, showing they induce cross-reactive immunity and neutralizing responses against SARS-CoV-2 and related coronaviruses.

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Scalable Antigen-Antibody Binding Affinity Landscape: A Case Study with ENHERTU

This paper develops a scalable computational workflow to generate antigen-antibody binding affinity landscapes, focusing on Trastuzumab, to improve ADC design and AI-based drug discovery.

Strawberry COP9 signalosome FvCSN5A regulates plant development and fruit ripening by facilitating polyamine oxidase FvPAO5 degradation to control polyamine and H2O2 homeostasis

This study identifies FvCSN5A as a regulator of polyamine and H2O2 homeostasis in strawberries by controlling FvPAO5 degradation, affecting plant development and fruit ripening.

Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

This study shows that Lacticaseibacillus rhamnosus P118 enhances host resistance to Salmonella by promoting indole metabolites from gut microbes.

Hepatic lipopolysaccharide binding protein partially uncouples inflammation from fibrosis in MAFLD

This study shows that reducing hepatic LBP in mice limits inflammation but not fibrosis in MAFLD, suggesting inflammation may not be a primary driver of fibrosis.

Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications in a common base culture media system

This study shows that tumoroids from six cancer types can be maintained long-term in a standardized serum-free medium, preserving their genetic and phenotypic features.

Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma

This study shows that combining FACT and BET inhibition disrupts oncogenic transcription and extends survival in Diffuse Midline Glioma models.

Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer

This study evaluates the biological activity of 60c, a next-generation colchicine-binding site inhibitor, showing improved potency and anti-metastatic effects in triple-negative breast cancer models.

Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Sodium/Potassium ATPase Alpha 1 Subunit Fine-tunes Platelet GPCR Signaling Function and is Essential for Thrombosis

This study shows that NKA 1 enhances platelet GPCR signaling and thrombosis by binding to LGL-containing receptors, and its inhibition reduces thrombosis and sensitizes clopidogrel.

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

This study investigates nearest-neighbor cooperativity in TRAP by engineering dTRAP variants and using cryo-EM and thermodynamic analyses to reveal structural and thermodynamic mechanisms of ligand binding cooperativity.

Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

This study shows that SMAD4 and KRAS mutations influence stromal composition and therapeutic response in pancreatic cancer models.

Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption

The paper analyzes single-cell transcriptomes of aortic smooth muscle cells in mice to show distinct origins and similar transcriptional changes after TGFβ signaling disruption.

Comparison of therapeutic effects between pulsed field ablation and cryoballoon ablation in the treatment of atrial fibrillation: a systematic review and me-ta-analysis

This study compares pulsed field ablation (PFA) and cryoballoon ablation (CBA) for atrial fibrillation treatment, finding PFA reduces surgical time and complications but not arrhythmia recurrence.

Identification of a distinct ductal subpopulation with self-renewal and differentiation potential from the adult murine pancreas

The paper identifies a rare ductal cell subpopulation in adult mice with progenitor-like properties that contribute to pancreas regeneration and tumor progression.

Transcriptome-wide mRNP condensation precedes stress granuleformation and excludes new mRNAs

The paper shows that mRNAs condense broadly in yeast under stress, independent of length, and new transcripts escape this condensation for selective translation.

Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice

This study shows that deleting Rbpj in hepatic progenitor cells reduces fibrosis and endothelial responses in DDC-fed mice by downregulating VCAM1 expression.

An effector XopL enhances ethylene biosynthesis to promote Xanthomonas fragariae infection in strawberry

This study identifies XopL as an effector that enhances ethylene biosynthesis in strawberry, promoting Xanthomonas fragariae infection by stabilizing FveACO9 and increasing ACO activity.

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

Differential Proteomic Analysis of AML Patients at Low and Intermediate Altitudes after Chemotherapy

This study identifies proteomic differences between AML patients at low and intermediate altitudes after chemotherapy, highlighting variations in metabolic and signaling pathways.

Structural basis for CCR6 modulation by allosteric antagonists

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.