CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under control of antigen sensing in microwell arrays
Y. Cho, M. Laird, T. Bishop, R. Li, E. Ruffo, J. Lohmueller, I. K. Zervantonakis
This study uses a microwell platform to analyze CAR T cell infiltration and cytotoxicity in 3D breast cancer spheroids, identifying factors like spheroid size and seeding density that influence anti-tumor activity.
bioRxiv · Mar 14, 2024Bioengineering