J. Lohmueller

CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under control of antigen sensing in microwell arrays

This study uses a microwell platform to analyze CAR T cell infiltration and cytotoxicity in 3D breast cancer spheroids, identifying factors like spheroid size and seeding density that influence anti-tumor activity.

The co-stimulatory activity of Tim-3 requires Akt and MAPK signaling and immune synapse recruitment

This study identifies Akt and MAPK signaling as essential for Tim-3 co-stimulatory activity and shows that Tim-3 localization to the immune synapse is critical for its function.