Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes.
Y. Hong, E. S. Mackenzie, S. J. Firth, J. F. Bolton, L. J. Stewart, K. J. Waldron, K. Y. Djoko
This study shows that Cu stress in GAS leads to mis-regulation of Zn and Mn homeostasis, affecting growth and lactate secretion, without altering cellular Cu levels.
bioRxiv · Sep 28, 2022 · PreprintMicrobiology