Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain
J. Jores, L. Ma, P. Ssajjakambwe, E. Schieck, A. M. Liljander, S. Chandran, M. H. Stoffel, V. L. Cippa, Y. Arfi, N. Asad-Garcia, L. Falquet, P. Sirand-Pugnet, A. Blanchard, C. Lartigue, H. Posthaus, , S. Vashee
This paper attenuates a highly virulent Mycoplasma strain by deleting non-essential genes and demonstrates its safety in vivo using a goat model.
bioRxiv · Jan 10, 2019Microbiology