Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria
U. Kolthur-Seetharam, E. Shaw, M. Talwadekar, N. Mohan, A. Acharya
This study identifies SIRT4 as an anabolic factor that activates TORC1 signalling through glutamine sparing in mitochondria, linking mitochondrial function to metabolic regulation.
bioRxiv · May 12, 2019Physiology