U. Kolthur-Seetharam

This study shows that metabolic states like fed and fasted influence global protein fatty acylation, with glucose affecting palmitoylation and oleoylation through mitochondrial and retrograde signaling pathways.

The paper shows that hepatic microRNAs increase during fasting to anticipate refeeding, regulated by metabolic and circadian factors, with potential therapeutic implications for metabolic diseases.

This study identifies G9a and Sirt6 as epigenetic regulators that modulate host cholesterol accumulation, supporting Mycobacterium tuberculosis survival.

This study identifies SIRT4 as an anabolic factor that activates TORC1 signalling through glutamine sparing in mitochondria, linking mitochondrial function to metabolic regulation.

This study identifies nutrient-dependent O-GlcNAcylation of SIRT1 as a mechanism controlling hepatic metabolism and insulin signaling during fasted-to-refed transitions.

This study shows that loss of mitochondrial dSirt4 reduces lifespan and impairs physical activity in flies.