Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.
E. Armstrong, M. K. L. Chiu, S. Foo, L. Appleton, P. Nenclares, A. Patrikeev, N. Mohan, M. McLaughlin, G. Bozhanova, J. Hoebart, V. Roulstone, E. C. Patin, M. Pedersen, J. Kyula, F. Errington-Mais, , V. A. Jennings
This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.
bioRxiv · Apr 2, 2024Cancer Biology