Author

E. Sheeky

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Biochemistry· 1

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Approach:experimental assay· 1

Frequent Co-Authors

B. E. Moeller· 1 shared C. K. Yip· 1 shared H. Ranga-Prasad· 1 shared J. E. Burke· 1 shared M. A. Parson· 1 shared M. K. Rathinaswamy· 1 shared M. L. Jenkins· 1 shared N. J. Harris· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

B. E. Moeller

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1 paper

Recent·Most cited

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

N. J. Harris, M. L. Jenkins, S.-E. Nam, M. K. Rathinaswamy, M. A. Parson, H. Ranga-Prasad, U. Dalwadi, B. E. Moeller, E. Sheeky, S. D. Hansen, C. K. Yip, J. E. Burke

This study identifies the helical domain of p110γ as an allosteric regulator of PI3Kγ activity, showing distinct roles in p110γ-p84 and p110γ-p101 complexes through phosphorylation or nanobody binding.

bioRxiv · Apr 12, 2023Biochemistry