C. K. Yip

Molecular basis for plasma membrane recruitment of PI4KA by EFR3

The paper reports a cryo-EM structure of EFR3A bound to the PI4KA complex, revealing the molecular mechanism of PI4KA membrane recruitment and its regulation in human disease.

Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A

The paper reports a cryo-EM structure of Calcineurin bound to PI4KA, revealing direct interactions with both PI4KA and FAM126A and their conserved binding sequences.

Probing the physiological role of the plastid outer-envelope membrane using the oemiR plasmid collection

The paper uses oemiR plasmids to downregulate OE protein transcripts, identifying roles in cold tolerance and revealing compensatory import pathways in Arabidopsis.

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

This study identifies the helical domain of p110γ as an allosteric regulator of PI3Kγ activity, showing distinct roles in p110γ-p84 and p110γ-p101 complexes through phosphorylation or nanobody binding.

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

This study identifies molecular differences between p110γ-p84 and p110γ-p101 complexes that explain their differential activation by GPCRs and Ras.

Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation

The paper reports the cryo-EM structure of the p110γ-p101 complex, revealing how GPCR activation is mediated through interactions with Gβγ and identifying potential therapeutic targets.

Biochemical insight into novel Rab-GEF activity of the mammalian TRAPPIII complex

This study investigates the GEF activity of TRAPPIII and TRAPPII complexes toward Rab GTPases using biochemical and structural methods, revealing Rab specificity and membrane interaction mechanisms.

HDX-MS optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

This paper uses HDX-MS to characterize nanobodies targeting PI3K{gamma} complexes, identifying epitopes and functional effects on lipid kinase activity and GPCR activation.