From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline
S. Rao, J. A. Somarelli, E. Altunel, L. E. Selmic, M. Byrum, M. U. Sheth, S. Cheng, K. E. Ware, S. Y. Kim, J. A. Prinz, N. Devos, D. L. Corcoran, A. Moseley, E. Soderblom, S. D. Hsu, W. C. Eward
This paper develops a cross-species personalized medicine pipeline using canine sarcomas to identify new treatments, finding proteasome inhibitors initially effective but limited by tumor heterogeneity.
bioRxiv · Jan 10, 2019Cancer Biology