S. Y. Kim

This study identifies pleural macrophages migrating to the lung during influenza infection, which correlates with improved disease outcomes.

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

The paper investigates the effect of physiologic TGF-beta doses on engineered cartilage composition, finding that lower doses improve neocartilage properties compared to supraphysiologic doses.

The paper identifies JAK/STAT signaling as a therapeutic target for Snail-induced enzalutamide-resistant prostate cancer through synthetic lethal screens and validation in a resistant cell model.

This study identifies T4 DNA polymerase as a tool to enhance CRISPR/Cas9 editing precision by reducing on-target deletions and translocations while increasing insertion accuracy.

This study shows that choline metabolism is essential for IL-4-induced macrophage polarization and RELMα expression during helminth infection, affecting immune homeostasis and parasite clearance.

The paper combines field observations and genomic data from baboons to study admixture and gene regulatory divergence, finding selection against introgression similar to archaic hominins.

The paper explores using toxin-antitoxin complexes as a novel drug target through fragment-based drug discovery, identifying MAB3862 as an antitoxin and demonstrating a strategy for inhibitor design.

This study characterizes non-covalently associated streptavidin nanohubs as stable protein-network materials with properties similar to chemically bonded hydrogels.

This study tracks endoscopic changes in IL-10 knockout mice and finds that 40% do not develop colitis, with all cases resolving spontaneously.

This paper identifies an Alu element insertion in the TBXT gene as the genetic mechanism driving tail-loss evolution in hominoids, showing it causes alternative splicing and tail absence in mice.

This study uses AcePET to visualize tumor boundaries and reactive astrocytes in GBM, showing that targeting MCT1 improves survival by enabling complete resection of cancer stem cells.

This study identifies ERELEE4 as an ORA59-binding cis-element and shows ORA59 regulates JA/ET-responsive genes through direct promoter binding, with differential preference for GCC box and ERELEE4 based on hormone activation.

This study develops a cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma, finding that dual inhibition of proteasome and CRM1 pathways induces synergistic cytotoxicity.

This study examines the effect of different peak inflation pressures during sustained inflation in neonatal resuscitation of asphyxiated piglets, finding similar time to ROSC but increased inflammation with higher pressure.

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

The paper identifies MTHFD1 as a target for broad antiviral therapy by screening bat cells with RNAi and CRISPR libraries against mumps and influenza viruses.

This study shows that all three Tad operons in Vibrio vulnificus are required for pathogenicity, as they enable host invasion, survival in blood, and resistance to complement activation through Flp pili.

The paper maps gene expression in human spermatogenesis and finds that expressed genes have fewer germline mutations, suggesting transcriptional scanning reduces DNA damage and influences gene evolution rates.

This paper develops a cross-species personalized medicine pipeline using canine sarcomas to identify new treatments, finding proteasome inhibitors initially effective but limited by tumor heterogeneity.

This study identifies 19-hydroxyandrostenedione as an endogenous agonist of OR51E2 that induces neuroendocrine trans-differentiation in prostate cancer cells.