W. C. Eward

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

This study analyzes the carcinogenic potential of 2,712 plastic additives using toxicogenomic methods, finding over 150 known carcinogens and most lacking carcinogenicity data.

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.

This study identifies ALOX5 upregulation during breath-holding in dolphins as a potential molecular mechanism for ischemic tolerance during diving.

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

This paper develops a cross-species personalized medicine pipeline using canine sarcomas to identify new treatments, finding proteasome inhibitors initially effective but limited by tumor heterogeneity.