Author

D. L. Corcoran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

J. A. Somarelli· 3 shared K. E. Ware· 3 shared W. C. Eward· 3 shared M. U. Sheth· 2 shared N. Devos· 2 shared A. Agarwal· 1 shared A. Fahlman· 1 shared A. J. Armstrong· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

J. A. Somarelli

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Author profile →

4 papers

Recent·Most cited

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

W. Floyd, M. Pierpoint, C. Su, L. Luo, K. Deland, A. J. Wisdom, D. Zhu, Y. Ma, S. B. DeWitt, N. T. Williams, J. A. Somarelli, D. L. Corcoran, W. C. Eward, D. M. Cardona, D. G. Kirsch

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

Journal of Clinical Investigation · Jul 3, 2023Peer-reviewedCancer Biology

An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins

A. M. Blawas, K. E. Ware, E. Schmaltz, L. Zheng, J. Spruance, A. S. Allen, N. West, N. Devos, D. L. Corcoran, D. P. Nowacek, W. C. Eward, A. Fahlman, J. A. Somarelli

This study identifies ALOX5 upregulation during breath-holding in dolphins as a potential molecular mechanism for ischemic tolerance during diving.

bioRxiv · Jan 20, 2021Physiology

Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

K. E. Ware, S. Gupta, J. Eng, G. Kemeny, B. J. Puviindran, W.-C. Foo, L. A. Crawford, R. G. Almquist, D. Runyambo, B. C. Thomas, M. U. Sheth, A. Agarwal, M. Pierobon, E. F. Petricoin, D. L. Corcoran, , J. Somarelli

This study identifies p38/MAPK pathway activation as a convergent mechanism driving survival, immune evasion, and metastasis in hormone-resistant prostate cancer.

bioRxiv · Apr 22, 2020 · PreprintCancer Biology

From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline

S. Rao, J. A. Somarelli, E. Altunel, L. E. Selmic, M. Byrum, M. U. Sheth, S. Cheng, K. E. Ware, S. Y. Kim, J. A. Prinz, N. Devos, D. L. Corcoran, A. Moseley, E. Soderblom, S. D. Hsu, W. C. Eward

This paper develops a cross-species personalized medicine pipeline using canine sarcomas to identify new treatments, finding proteasome inhibitors initially effective but limited by tumor heterogeneity.

bioRxiv · Jan 10, 2019Cancer Biology