Aldehydic load as an objective imaging biomarker of mild traumatic brain injury
A. Kirby, C. Ward, N. D. Calvert, R. Daniel, J. W.-H. Leung, A. Shawma, M. Suchy, C. Donatelli, J. Wang, E. Standen, A. J. Shuhendler
This study develops a CEST-MRI contrast agent to detect aldehydes in mTBI, showing increased aldehyde levels and neuroinflammation in mice with ALDH2 deficiency.
bioRxiv · Apr 16, 2024Biochemistry