C. Ward

Acute microtubule changes linked to DMD pathology are insufficient to impair contractile function or enhance contraction-induced injury in healthy muscle

This study investigates the impact of microtubule alterations in DMD muscle, finding no impairment in contractile function but some protection against contraction injury with pharmacologic treatment.

Aldehydic load as an objective imaging biomarker of mild traumatic brain injury

This study develops a CEST-MRI contrast agent to detect aldehydes in mTBI, showing increased aldehyde levels and neuroinflammation in mice with ALDH2 deficiency.

Airway succinate chemosensing induces CFTR-dependent anion secretion and mucus clearance which is impaired in cystic fibrosis.

Na+/K+ATPase - Cav1.2 nanodomain differentially regulates intracellular and local adrenergic signaling in cardiac myocytes

The paper investigates how the NKA1-Cav1.2 nanodomain differentially regulates intracellular Na+ and Ca2+ homeostasis in atrial and ventricular myocytes through local adrenergic signaling.

Surface temperatures are influenced by handling stress independently of corticosterone levels in wild king penguins (Aptenodytes patagonicus)

This study uses thermal imaging to show that handling stress increases adult eye temperature and decreases beak temperature, but corticosterone levels do not affect surface temperatures in king penguins.

Myofibrillar malformations that arise in mdx muscle fibers are driven by detyrosinated microtubules

This study identifies detyrosinated microtubules as a driver of myofibrillar malformations in dystrophic skeletal muscle fibers, linking increased deTyr-MT levels to structural impairments.

Conjunctival epithelial cells resist productive SARS-CoV-2 infection

The paper investigates whether conjunctival epithelial cells can be infected by SARS-CoV-2 and finds that while genome expression occurs, productive infection does not.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

Global Profiling of the Lysine Crotonylome in Different Pluripotent States

This study profiles protein crotonylation in different mouse pluripotent states, identifying 3628 sites and showing that crotonyl-CoA promotes proteasome activity and delays differentiation.

MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cells

This study shows MYBL2 activates ATM to suppress replication stress in ESCs, with loss of MYBL2 or ATM causing replication fork slowing and increased origin firing.

Ablation of MYB-dependent leukaemia phenotype in MLL-driven AML correlates with increased expression of MAFB.

The paper shows that MYB ablation in MLL-driven AML increases MAFB expression, while this effect is absent in AML with complex karyotypes.

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

Assessing genomic admixture between cryptic Plutella moth species following secondary contact

The paper assesses genomic admixture between two cryptic Plutella moth species, finding reproductive isolation despite their ability to hybridize.

The intrinsic predictability of ecological time series and its potential to guide forecasting

The paper quantifies intrinsic predictability of ecological time series using permutation entropy and shows its relationship with model forecasting error.