Label-free 3-D molecular imaging of living tissues using Raman Spectral Projection Tomography
E. Stepula, A. R. Walther, D. Mehrotra, M. Jensen, M. H. Yuan, S. V. Pedersen, E. Gentleman, M. B. Albro, M. A. B. Hedegaard, M. S. Bergholt
This paper introduces Raman spectral projection tomography (RSPT) for label-free 3-D molecular imaging of tissues with sub-millimeter resolution and demonstrates its application in imaging molecular gradients and extracellular matrix heterogeneities.
bioRxiv · Sep 23, 2023 · PreprintBioengineering