M. Jensen

Femtosecond X-ray snapshots reveal correlated displacements of specific distal atoms in a protein crystal

The paper uses femtosecond X-ray diffraction to study atomic displacements in bovine trypsin crystals, showing correlated movements influenced by THz pulses and atomic type.

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

Leveraging a large language model to predict protein phase transition: a physical, multiscale and interpretable approach

This paper fine-tunes a large language model to predict protein phase transitions from sequence data and shows its utility in assessing sequence variants' effects on aggregation and droplet formation.

Label-free 3-D molecular imaging of living tissues using Raman Spectral Projection Tomography

This paper introduces Raman spectral projection tomography (RSPT) for label-free 3-D molecular imaging of tissues with sub-millimeter resolution and demonstrates its application in imaging molecular gradients and extracellular matrix heterogeneities.

Opto-lipidomics of tissues

This study introduces opto-lipidomics, a technique that uses vibrational Raman spectroscopy combined with mass spectrometry to visualize and identify lipids in tissues with high molecular specificity.

Nondestructive Spatial Lipidomics for Glioma Classification

This study develops a nondestructive method using nanoneedles and mass spectrometry to perform spatial lipidomics on brain tissues, enabling accurate glioma classification without damaging the tissue.

Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings

This paper develops pCBMA hydrogel coatings for cochlear implants to reduce the foreign body response, showing reduced capsule thickness and inflammation in vivo.

De novo phytosterol synthesis in animals

The paper shows marine annelids synthesize sitosterol, a phytosterol, challenging the assumption that phytosterol synthesis is exclusive to plants.

Evaluation of RNAlater™ as a field-compatible preservation method for metaproteomic analyses of bacteria-animal symbioses

This study evaluates RNAlater as a field-compatible preservation method for metaproteomics, finding it preserves proteins as effectively as flash freezing and remains stable for up to 4 weeks at room temperature.

Raman Needle Arthroscopy for In Vivo Molecular Assessment of Cartilage

This paper introduces a Raman needle arthroscopy technique to assess cartilage health in vivo by quantifying ECM biomarkers like GAG and collagen, showing high predictive accuracy in ex vivo models and demonstrating its first in vivo use.

Ultra-sensitive Protein-SIP to quantify activity and substrate uptake in microbiomes with stable isotopes

This paper introduces Protein-SIP, an ultra-sensitive method for quantifying isotope incorporation in microbiomes, showing higher sensitivity and accuracy than existing approaches.

Critical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows

CAMPI evaluates metaproteomic workflows across labs, finding sample processing drives peptide variability while workflows yield similar functional profiles.

A CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue

The paper develops a CAR RNA FISH assay to study the trafficking and function of CAR T cells in mouse tissue at single-cell resolution.

Antibody-mediated immobilization of virions in mucus

This study analyzes virion movement in mucus using single-particle tracking to show how antibodies immobilize virions through cooperative binding and entanglement with mucin.

FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest

This study shows that alcohol increases FGF21 levels in humans and that FGF21 reduces alcohol intake in mice.