Author

E. Stratikos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Organism:virus· 1

Frequent Co-Authors

A. Mpakali· 2 shared G. Panayotou· 2 shared G. Stamatakis· 2 shared I. Temponeras· 2 shared M. Samiotaki· 2 shared A. Cortes· 1 shared A. D. Hollander· 1 shared A. Mulder· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

A. Mpakali

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Author profile →

5 papers

Recent·Most cited

Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties

G. Georgaki, A. Mpakali, M. Trakada, A. Papakyriakou, E. Stratikos

This study investigates the enzymatic properties of ERAP1 allotype 10, showing that polymorphisms V349M and Q725R significantly affect its activity, kinetics, and thermodynamics compared to allotype 1.

bioRxiv · Mar 14, 2024Biochemistry

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 Spike Glycoprotein

G. Stamatakis, M. Samiotaki, I. Temponeras, G. Panayotou, E. Stratikos

The paper investigates how different ERAP1 allotypes affect antigen processing of SARS-CoV-2 S1 Spike Glycoprotein, revealing allotype-dependent sequence biases in peptide generation.

bioRxiv · Jul 3, 2021Biochemistry

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

H. P. Jonathan, I. Temponeras, J. Kuiper, A. Cortes, J. Korczynska, S. Kitchen, E. Stratikos

The paper characterizes the enzymatic properties of common ERAP1 allotypes and finds they show substrate-dependent activity variation, with one allotype consistently low in activity.

bioRxiv · Nov 19, 2020Biochemistry

ERAP2 increases the abundance of a peptide submotif highly selective for the Birdshot Uveitis-associated HLA-A29

W. Venema, S. Hiddingh, J. H. de Boer, F. Claas, A. Mulder, A. D. Hollander, E. Stratikos, S. Sarkizova, L. v. d. Veken, G. Janssen, P. v. Veelen, J. J. Kuiper

The paper investigates how ERAP2 affects HLA-A29 peptide presentation in BU and identifies an HLA-A29-specific peptide motif linked to autoantigens.

bioRxiv · Aug 14, 2020 · PreprintImmunology

Generation of SARS-CoV-2 S1 spike glycoprotein putative antigenic epitopes in vitro by intracellular aminopeptidases

G. Stamatakis, M. Samiotaki, A. Mpakali, G. Panayotou, E. Stratikos

The paper identifies SARS-CoV-2 S1 spike glycoprotein epitopes generated by aminopeptidases in vitro, showing limited overlap with computational predictions.

bioRxiv · Jun 22, 2020Biochemistry