Protein-lipid interaction at low pH induces oligomerisation of the MakA cytotoxin from Vibrio cholerae
A. Nadeem, A. Berg, H. Pace, A. Alam, E. Toh, J. Aden, N. Zlatkov, S. L. Myint, K. Persson, G. Gröbner, A. Sjöstedt, M. Bally, J. Barandun, B. E. Uhlin, S. N. Wai
This study shows that MakA, a Vibrio cholerae toxin, forms tube-like structures in acidic conditions through protein-lipid interactions, revealing a novel mechanism of membrane tubulation.
bioRxiv · Sep 10, 2021Cell Biology