A. Alam

Microbial Metabolite Trimethylamine N-Oxide Promotes Campylobacter jejuni Infection by Escalating Intestinal Inflammation, Epithelial Damage, and Barrier Disruption

This study shows that TMAO, a microbial metabolite, enhances C. jejuni infection by increasing intestinal inflammation, epithelial damage, and barrier disruption.

Colonic spermidine promotes the proliferation and migration of intestinal epithelial cells.

This study shows that colonic spermidine, produced by B. uniformis, promotes intestinal epithelial cell proliferation and migration during gut repair.

AI-based antibody discovery platform identifies novel, diverse and pharmacologically active therapeutic antibodies against multiple SARS-CoV-2 strains

This paper presents an AI-based platform for rapid antibody discovery against SARS-CoV-2, identifying novel therapeutic antibodies effective against multiple strains.

Protein-lipid interaction at low pH induces oligomerisation of the MakA cytotoxin from Vibrio cholerae

This study shows that MakA, a Vibrio cholerae toxin, forms tube-like structures in acidic conditions through protein-lipid interactions, revealing a novel mechanism of membrane tubulation.

Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment

This study determines cryo-EM structures of ABCD1 in lipid environments, revealing transport mechanism and disease-related structural features.

How sequence context-dependent mutability drives mutation rate variation in the genome

The paper simulates how sequence context-dependent mutability affects mutation rate equilibrium and purifying selection in the human genome.

A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion

This paper identifies a tripartite cytolytic toxin from Vibrio cholerae, showing that MakA/B/E proteins are secreted via flagella and form pores in membranes, contributing to bacterial virulence.

Capturing the interplay of membrane lipids and structural transitions in human ABCA7

This study presents cryo-EM structures of human ABCA7 in open and closed states, revealing lipid interactions and conformational changes, supported by functional analysis and MD simulations.