BiochemistrybioRxiv
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
T. Karlberg, P. Hornyak, A. F. Pinto…·H. Schuler
This study identifies a novel hydrophobic interface between 14-3-3 proteins and Pseudomonas exotoxins-S and -T, showing 14-3-3 activates these toxins by preventing aggregation, independent of their C-terminal phosphopeptide binding motifs.
DOI 10.1038/s41467-018-06194-1