Bile acid dependent attenuation of toxin mediated disease is independent of colonization resistance against C. difficile
Samantha C. Kisthardt, Caroline E. Perkins, Abigail Shahar Gancz, Noah S. Lyons, Stéphanie Thomas, E. Vincent, Guozhi Zhang, John Tam, Roman A. Melnyk, Elizabeth C. Rose, Erin Shammel Baker, Casey M. Theriot
This study shows that secondary bile acid metabolism, not nutrient competition, reduces C. difficile toxin-mediated disease in vivo, independent of colonization resistance.
bioRxiv · Mar 12, 2026 · PreprintMicrobiology