Author

Guozhi Zhang

University of North Carolina at Chapel HillORCID 0000-0002-4819-3580Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:benchmarking· 1 Assay:metagenomics· 1

Frequent Co-Authors

Casey M. TheriotiD· 3 shared Erin Shammel BakeriD· 3 shared E. Vincent· 2 shared Abigail Shahar GancziD· 1 shared Abubaker PataniD· 1 shared Ajay S GulatiiD· 1 shared Arthur S. McMillaniD· 1 shared Caroline E. Perkins· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Casey M. TheriotORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 12, 2026

Bile acid dependent attenuation of toxin mediated disease is independent of colonization resistance against C. difficile

Samantha C. Kisthardt, Caroline E. Perkins, Abigail Shahar Gancz…·Casey M. Theriot

This study shows that secondary bile acid metabolism, not nutrient competition, reduces C. difficile toxin-mediated disease in vivo, independent of colonization resistance.

2 citations

humanexperimental assay

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MicrobiologySustainable MicrobiologyPeer-reviewedJan 1, 2026

Unlocking the Bile Acid Universe: Advanced Workflows and a Multidimensional Library of 280 Unique Species

Guozhi Zhang, E. Vincent, Sadie M. Disselkoen…·Erin Shammel Baker

The paper develops a multidimensional bile acid reference library and evaluates workflows for accurate bile acid measurement in biological samples.

DOI 10.1093/sumbio/qvag039

metabolomicsexperimental assay

𝕏 PostBluesky

MicrobiologymSpherePeer-reviewedOct 8, 2024

Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection

Arthur S. McMillan, Guozhi Zhang, Michael K Dougherty…·Casey M. Theriot

This study examines changes in microbiome, metabolome, and lipidome after fecal microbiota transplantation for recurrent C. difficile infection, identifying lipid and bile acid shifts linked to treatment success.

40 citationstop 1%

humanmetagenomics

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