The landscape of intrinsic and evolved fluoroquinolone resistance in Acinetobacter baumannii includes suppression of drug-induced prophage replication
E. Geisinger, G. Vargas-Cuebas, N. J. Mortman, S. Syal, E. Wainwright, D. W. Lazinski, S. Wood, Z. Zhu, J. Anthony, T. van Opijnen, R. R. Isberg
This paper identifies mutations that alter fluoroquinolone sensitivity in Acinetobacter baumannii and shows that preferential Topo IV poisoning leads to prophage induction and SOS response activation.
bioRxiv · Oct 14, 2018 · PreprintMicrobiology