A bacterial pan-genome makes gene essentiality strain-dependent and evolvable
F. Rosconi, E. Rudmann, J. Li, D. Surujon, J. Anthony, M. Frank, D. S. Jones, C. Rock, J. W. Rosch, C. D. Johnston, T. van Opijnen
The paper investigates how a bacterial pan-genome affects gene essentiality and shows that essential genes can evolve to become non-essential through genetic changes and mechanisms like functional redundancy and pathway rewiring.
bioRxiv · Feb 8, 2022Microbiology