R. R. Isberg

The paper identifies proteins essential for maintaining fitness in Acinetobacter baumannii strains overexpressing RND efflux pumps, highlighting the role of outer membrane integrity and compensatory mechanisms.

This study shows Sde proteins in Legionella pneumophila use deubiquitination and phosphoribosylation to manipulate host ER structure and evade autophagy.

This study shows that Legionella pneumophila uses Sde proteins to modify Rtn4, forming ER aggregates that protect the Legionella-containing vacuole from host disruption.

This study identifies Sde proteins as temporally-regulated vacuole guards in Legionella pneumophila that prevent early vacuole disruption by blocking host endosomal trafficking.

This study identifies genes essential for Legionella pneumophila survival in water using Tn-seq and CRISPRi, showing that electron transport chain genes and cell wall stability factors are critical for long-term viability.

This study identifies host proteins selectively synthesized during Legionella pneumophila infection and shows that 5' untranslated regions (5UTRs) enable translation of low-abundance transcripts despite host translation inhibition.

This study uses human ileal enteroid-derived monolayers to show that Yersinia pseudotuberculosis YopE prevents uptake by M cells and causes their extrusion, facilitating bacterial transcytosis.

This study shows that Legionella pneumophila Sde proteins can ubiquitinate tyrosine residues, not just serine, challenging previous assumptions about their substrate specificity.

This study shows that immunosuppression promotes antibiotic resistance evolution in Acinetobacter baumannii pneumonia by enabling persistence mutations that cause treatment failure without clinical resistance.

The study shows that reduced YopJ function in Yersinia species correlates with increased virulence in mice, suggesting that decreased cytotoxicity enhances pathogenesis.

The paper shows SdhA blocks OCRL phosphatase to maintain Legionella vacuole integrity, preventing bacterial degradation.

This study identifies essential genes in Acinetobacter baumannii using transposon mutagenesis and a CRISPRi system, revealing new factors and conditionally essential processes.

The paper reconstructs microbial social behavior in deep tissue sites using microfluidics-driven microdroplets and NO generation, mimicking spatial regulation observed in tissues.

This study identifies antibiotic hypersensitivity signatures in A. baumannii to discover new targets for attacking the pathogen's cell envelope.

The paper identifies host Rab GTPases and their effectors that disrupt vacuole integrity during Legionella pneumophila infection, showing their role in destabilizing the Legionella-containing vacuole.

This study shows that Y. pseudotuberculosis uses Fe-S cluster repair via YtfE to survive in the spleen under nitrosative stress, even when NO detoxification is absent.

This study shows that Legionella pneumophila uses translation inhibitors to block host cell cycle progression and prevent entry into S phase, which is toxic for bacterial replication.