Z. Zhu

This paper develops a dual-gene reporter-amplifier system to enhance MRI sensitivity by using Aqp1 to facilitate water exchange, enabling detection of low-abundance Oatp1b3-expressing cells.

This study shows CHI3L1 inhibits macrophage phagocytosis by modulating CD47-SIRPα and CD24-Siglec10 pathways, contributing to immune evasion in cancer and COPD.

The paper traces the evolutionary emergence of the prion-like domain in ELF3 across the plant kingdom, finding polyQ repeat length variation in Arabidopsis thaliana but weak association with environmental adaptation.

This study presents cryo-EM structures of VMAT2 bound to substrates and inhibitors, revealing conformational changes and mechanisms of ligand recognition and inhibition.

The paper investigates the genetic interactions between ELF3, PRR9, and PRR7 in Arabidopsis, revealing complex epistatic relationships affecting circadian rhythms and plant development.

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

This study shows that H3.3-G34R mutations reprogram the tumor immune microenvironment in diffuse hemispheric gliomas, enhancing the efficacy of immune stimulatory gene therapy and leading to long-term survival in treated mice.

This study shows Rme-6 coordinates EGFR trafficking and signaling to regulate ERK1/2 signalosome dynamics through CK2-mediated phosphorylation and endocytic trafficking.

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

The paper identifies chromatin classes in RA synovial tissue and links them to transcriptional cell states and genetic variants.

This paper shows that Toxoplasma gondii infection changes dendritic cell durotaxis by altering F-actin structure and FAK phosphorylation, promoting parasite brain dissemination.

The paper presents a simple model that explains global greenness patterns and trends using two parameters, matching the accuracy of complex vegetation models.

This study identifies Dbh+ neurons in the brainstem as critical for chronic allergen-induced airway hyperreactivity through molecular, anatomical, and functional analyses.

This study examines how changes in intraocular and intracranial pressures affect monkey optic nerve head morphology, finding nonlinear and non-monotonic deformations not explained by translaminar pressure difference.

The paper investigates the T492I mutation in SARS-CoV-2 NSP4, showing it increases transmissibility, replication, and antibody evasion by enhancing NSP5 cleavage efficiency and reducing viral RNA-associated chemokines.

This study develops a CRISPR-Cas12a-based sensor enhanced with graphene oxide for specific and sensitive detection of amyloid-β oligomers, aiming to enable early Alzheimer's disease diagnosis.

The paper investigates γ-tubulin complex recruitment mechanisms at mitotic centrosomes in Drosophila, showing that Spd-2 and Cnn use different pathways to nucleate microtubules, with implications for centrosome robustness and microtubule dynamics.

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

This study identifies FBXO11 loss as a driver of AML by promoting a stem cell program through mitochondrial dysregulation.

This study shows an exotic barley ELF3 allele improves yield stability at high temperatures by altering growth and developmental responses.

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

The paper develops a cell culture medium mimicking the PDAC tumor microenvironment and identifies arginine biosynthesis as a metabolic adaptation to myeloid-driven arginine starvation.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.